TRPS1 Gene

The TRPS1 gene also known as Transcriptional Repressor GATA Binding 1 gene is a protein coding gene located on chromosome 8q23.3.

The TRPS1 gene encodes a transcription factor that represses GATA-regulated genes. Here, TRPS1 binds specifically to GATA sequences and represses the expression of GATA-regulated genes at selected sites and stages of vertebrate development. Binding of the encoded protein to the light chain protein impairs binding to GATA consensus sequences and represses its transcriptional activity. This regulates chondrocyte proliferation and differentiation.

Diseases associated with TRPS1 include:

• Trichorhinophalangeal Syndrome, Type Iii and
• Trichorhinophalangeal syndrome, type I.

TRPS1 is expressed in all four subtypes of breast carcinoma (Ai D et al. 2021).Here, TRPS1 and GATA3 show comparable positive expression in ER-positive (98% vs. 95%) and HER2-positive (87% vs. 88%) (Ai D et al. 2021).

TRPS1 regulates chondrocyte proliferation and differentiation. Performs multiple functions in proliferating chondrocytes, expands the range of distal chondrocytes, activates proliferation in columnar cells, and supports differentiation of columnar into hypertrophic chondrocytes.

1. Ai D et al. (2021) TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer. Mod Pathol 34:710-719.
2. Liu H et al. (2018) Trps1 is associated with the multidrug resistance of lung cancer cell by regulating MGMT gene expression. Cancer Med 7:1921-1932.
3. Redig AJ et al (2013) Breast cancer as a systemic disease: a view of metastasis. J Intern Med 274:113-126.