TNFRSF6B Gene

TNFRSF6B (TNF Receptor Superfamily Member 6b), also called Decoy Receptor 3, is a protein-coding gene located on chromosome 20q13.33.

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is thought to play a regulatory role in the suppression of FasL- and LIGHT-mediated apoptosis. It functions as a decoy receptor (a decoy receptor (translatable as "mock receptor; decoy receptor" is a specific receptor that binds its ligand with high affinity but does not transmit signals) that competes with death receptors for ligand binding. Overexpression of this gene has been found in tumors of the gastrointestinal tract.

Diseases associated with TNFRSF6B include:

• Proliferative extracapillary glomerulonephritis,also known as "Idiopathic Crescentic Glomerulonephritis", which usually presents clinically as Rapid progressive glomerulonephritis with hematuria, proteinuria and rapidly deteriorating renal function.

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2. Weng SC et al (2019) Role of prognostic biomarker decoy receptor 3 and immunomodulation in kidney diseases. J Chin Med Assoc 82:680-684.