DefinitionThis section has been translated automatically.
TNFAIP3 (TNF Alpha Induced Protein 3) is a protein coding gene located on chromosome 6q23.3. Multiple transcript variants encoding the same protein have been found for this gene. TNFAIP3 was also characterized as a primary response gene of TNF, IL1-β, and LPS, as each cytokine triggered rapid, transient, and robust induction of the TNFAIP3 transcript independent of de novo protein synthesis.
General informationThis section has been translated automatically.
The protein encoded by this gene is a zinc finger protein- and ubiquitin-editing enzyme and has been shown to inhibit NF-kappa B activation and TNF-mediated apoptosis. The enzyme exhibits both ubiquitin ligase and deubiquitinase activities, is involved in cytokine-mediated immune and inflammatory responses signaled by cytokines such as TNF-alpha and IL-1 beta or by pathogens via Toll-like receptors (TLRs) by terminating NF-kappa B activity. It is recognized as a key inhibitor of inflammation, cell death and tumorigenesis. In summary, tumor necrosis factor-alpha-induced protein 3 plays a primary role in attenuating pro-inflammatory signaling pathways.
Diseases associated with TNFAIP3 include:
- Autoinflammatory syndrome, familial, Behcet-like (OMIM: 616744).
- and
- Primary mediastinal B-cell lymphoma.
