DefinitionThis section has been translated automatically.
The TIRAP gene (TIRAP stands for "TIR Domain Containing Adaptor Protein") is a protein-coding gene located on chromosome 11q24.2. Alternative splicing of this gene results in multiple transcript variants.
Note: The innate immune system recognizes microbial pathogens via Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns, and all Toll-like receptors have a Toll interleukin-1 receptor (TIR) domain responsible for signal transduction.
General informationThis section has been translated automatically.
The encoded protein is an adaptor protein involved in TLR2 and TLR4 signaling pathways in innate immune response. It positively regulates the production of TNF-alpha and interleukin-6 and acts through IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and thus cytokine secretion and inflammatory response.
LiteratureThis section has been translated automatically.
- Takeda K et al (2005) Toll-like receptors in innate immunity. Int Immunol 17:1-14.
