TCL1A also referred to as "TCL1 Family AKT Coactivator A" ( TCL1A = acronym for T Cell Leukemia/Lymphoma 1A) is a protein coding gene located on chromosome 14q32.13.
TCLA1 Gene
DefinitionThis section has been translated automatically.
General informationThis section has been translated automatically.
Overexpression of the TCL1 gene in humans has been associated with the development of mature T-cell leukemias. In these diseases, chromosomal rearrangements occur, placing the TCL1 gene near the regulatory elements of the T-cell antigen receptor (TCR)-alpha or TCR-beta (Virgilio L et al. 1994). In normal T cells, TCL1 is expressed in CD4/CD8 cells but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT.
Diseases associated with TCL1A include T-cell precursor acute lymphoblastic leukemia and T-cell prolymphocyte leukemia (Yokohama A et al. 2012). An important paralog of this gene is MTCP1.
LiteratureThis section has been translated automatically.
- Ropars Vet al. (2009) The TCL1A oncoprotein interacts directly with the NF-kappaB inhibitor IkappaB. PLoS One 4:e6567.
- Yokohama A et al. (2012) TCL1A gene involvement in T-cell prolymphocytic leukemia in Japanese patients. Int J Hematol 95:77-85.