TCLA1 Gene

TCL1A also referred to as "TCL1 Family AKT Coactivator A" ( TCL1A = acronym for T Cell Leukemia/Lymphoma 1A) is a protein coding gene located on chromosome 14q32.13.

Overexpression of the TCL1 gene in humans has been associated with the development of mature T-cell leukemias. In these diseases, chromosomal rearrangements occur, placing the TCL1 gene near the regulatory elements of the T-cell antigen receptor (TCR)-alpha or TCR-beta (Virgilio L et al. 1994). In normal T cells, TCL1 is expressed in CD4/CD8 cells but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT.

Diseases associated with TCL1A include T-cell precursor acute lymphoblastic leukemia and T-cell prolymphocyte leukemia (Yokohama A et al. 2012). An important paralog of this gene is MTCP1.

1. Ropars Vet al. (2009) The TCL1A oncoprotein interacts directly with the NF-kappaB inhibitor IkappaB. PLoS One 4:e6567.
2. Yokohama A et al. (2012) TCL1A gene involvement in T-cell prolymphocytic leukemia in Japanese patients. Int J Hematol 95:77-85.