STAT5B-gene

STAT5B (Signal Transducer And Activator Of Transcription 5B) is a protein coding gene located on chromosome 17q21.2. The STAT5A and STAT5B genes are located in an inverted orientation with their 5-prime ends approximately 11 kb apart.

Diseases associated with STAT5B include growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive and growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant.

Related signaling pathways include the ERK signaling pathway and the Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. Gene Ontology (GO) annotations associated with this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is STAT5A.

The protein STAT 5 encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, members of the STAT family are phosphorylated by receptor-associated kinases and then form homodimers or heterodimers that translocate to the nucleus where they act as transcriptional activators. This protein mediates signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1 and various growth hormones. It has been shown to be involved in various biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression.