SLC39A7 Gene

Last updated on: 09.06.2022

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).

Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

DefinitionThis section has been translated automatically.

The SLC39A7 gene (SLC39A7 stands for "Solute Carrier Family 39 Member 7") is a protein coding gene located on chromosome 6p21.32. Alternative splicing leads to several transcript variants.

General informationThis section has been translated automatically.

The protein encoded by the SLC39A7 gene is a zinc transporter that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+).

This transport is also likely to be important for the activation of tyrosine kinases, some of which may be involved in the development of malignancies. Therefore, modulation of the encoded protein could be useful as an oncologic.

Diseases associated with SLC39A7 include:

Agammaglobulinemia 9, autosomal recessive.

Last updated on: 09.06.2022