Rank

RANK is the acronym for "Receptor Activator of NF-κB". RANK is a transmembrane protein from the family of tumor necrosis factors (TNF), which is found in mammals and is expressed by maturation and adult osteoclasts. RANK is encoded by the TNFRSF11A gene.

RANK, together with its ligand RANKL (Receptor Activator of NF-κB ligand) and another regulatory protein osteoprotegerin (OPG), plays a key role in the regulation of bone remodeling.

For further details see RANKL below

1. Hanada R et al (2011) RANKL/RANKbeyond bones. Journal of Molecular Medicine 89: 647-656.
2. Hofbauer LC (2010) Importance of the RANK / RANKL / OPG signaling pathway for bone metabolism. Osteology 19: 354-357.
3. Kartsogiannis V et al.(1999) Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues. Bone 25, 525-34.
4. Keck AV et al (2003) Bone metabolism in malignant diseases. Journal for Mineral Metabolism (2003) 10:6-11
5. Luo J et al (2016) LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nature Medicine 22, 539-546.
6. Owen S et al (2013) Expression profile of receptor activator of nuclear-κb (rank), rank ligand (rankl) and osteoprotegerin (OPG) in breast cancer. Anticancer Research 33, 199-206.
7. Teitelbaum SL (2006) Osteoclasts; culprits in inflammatory osteolysis. Arthritis research and therapy 8: 201-206.
8. Zhang X et al (2017) RANKL/RANK pathway abrogates cetuximab sensitivity in gastric cancer cells via activation of EGFR and c-Src. OncoTargets and Therapy 10: 73-83.