PTPN22 gene

Last updated on: 25.04.2024

Dieser Artikel auf Deutsch

Definition
This section has been translated automatically.

The PTPN22 gene (PTPN22 stands for: Protein Tyrosine Phosphatase Non-Receptor Type 22) is a protein-coding gene located on chromosome 1p13.2. Alternatively spliced transcript variants encoding different isoforms have been described. An important paralog of this gene is PTPN12.

Literature
This section has been translated automatically.

  1. Bahrami T et al. (2020) PTPN22 Gene Polymorphisms in Pediatric Systemic Lupus Erythematosus. Fetal Pediatr Pathol 39:13-20.
  2. Wang Y et al. (2013) The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity 39:111-122).
  3. Wu J et al. (2006) Identification of substrates of human protein-tyrosine phosphatase PTPN22. J Biol Chem 281:11002-11010.
  4. Yu X et al. (2007) Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc Natl Acad Sci U S A 104:19767-72).

Last updated on: 25.04.2024

Articlecontent