PRDX1 gene

The PRDX1 gene (PRDX1 stands for: Peroxiredoxin 1) is a protein coding gene located on chromosome a1p34.1. An important paralog of this gene is PRDX2.

The PRDX1 gene encodes a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. This peroxidase plays a role in cell protection against oxidative stress by detoxifying peroxides and serving as a sensor for hydrogen peroxide-mediated signaling events.

The enzyme may be involved in growth factor and tumor necrosis factor-alpha signaling cascades by regulating intracellular concentrations of H(2)O(2) (Kang SW et al. 1998). Reduces an intramolecular disulfide bond in GDPD5 that prevents the ability of GDPD5 to drive postmitotic differentiation of motor neurons.

PRDX1 negatively regulates NF-kB activity by interfering with the TRAF6 and mitochondrial ECSIT complexes. This (immunosuppressive) process appears to play a role in Borrelia infection.

1. Kang SW et al. (1998) Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. J Biol Chem 273:6297-6302.
2. Kang JH et al. (2023) Extracellular Prdx1 mediates bacterial infection and inflammatory bone diseases. Life Sci 333:122140.
3. Wi SM et al. (2014) TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB. J Biol Chem 289:35205-35214.