The PMVK gene (PMVK stands for phosphomevalonate kinase) is a protein-coding gene located on chromosome 1q21.3.
The PMVK gene encodes a peroxisomal enzyme that belongs to the family of ATP-dependent enzymes galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP). Alternative splicing results in multiple transcript variants.
The encoded protein catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to form mevalonate diphosphate and ADP, a key step in the mevalonic acid-mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites. This is the fifth step in the mevalonate pathway of isoprenoid biosynthesis.