PCM1 Gene

PCM1 gene (PCM is the acronym for "Pericentriolar Material 1") refers to a protein-coding gene localized on chromosome 8p22. The protein encoded by this gene is a component of the centriolar satellites, i.e. the electron-dense granules localized around the centrosomes.

This protein has been shown to be essential for the correct localization of several centrosomal proteins and for the anchoring of microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a number of hematological malignancies , including atypicalchronic myeloid leukemia and T-cell lymphomas (Reiter A et al. 2017).

Several transcript variants encoding different isoforms have been found for this gene.

1. Reiter A et al (2017) Myeloid neoplasms with eosinophilia. Blood129:704-714.