Pateo syndrome T88.7

Childress and Lokich 2003

PATEO is an acronym for Periarticular Thenar Erythema with Onycholysis and refers to a drug-induced acral erythema that can occur especially with taxanes. This is a toxic cutaneous side effect of taxane-based chemotherapies. PATEO syndrome is a rare subtype of "hand-foot syndrome" that has been described in association with paclitaxel and docetaxel therapies.

Clinically, PATEO is characterized by redness of the ankle/ Achilles tendon region and/or palms, accentuated in the thenar and hypothenar regions, and by

Onycholysis of varying severity (classification according to"Common Terminyology Criteria for Adverse Events").

Taxanes usually cause skin changes on palms and soles. However, these may also occur "atypically" on other skin parts, such as the backs of the hands and feet as well as on the face. The onycholytic nail changes are usually observed after several docetaxel cycles, but gradually regress over the course of several weeks despite continued treatment (Ferreira O et al. 2010).

1. Ferreira O et al. (2010) Docetaxel-induced acral erythema and nail changes distributed to photoexposed areas. Cutan Ocul Toxicol 29:296-299.
2. Rodríguez-Lomba E et al. (2017) Periarticular Thenar Erythema and Onycholysis Syndrome; A Manifestation of Taxane-Induced Cutaneous Toxicity. Actas dermo-sifiliograficas 108:595-597.
3. Rzepecki AK et al. (2018) PATEO syndrome: periarticular thenar erythema with onycholysis.Acta Oncol 57:991-992.
4. Scotté F et al. (2008) Matched case-control phase 2 study to evaluate the use of a frozen sock to prevent docetaxel-induced onycholysis and cutaneous toxicity of the foot. Cancer 112:1625-1631.