One hand two feet syndrome B35.30

The "one hand two feet syndrome" describes a dermatophytosis with infestation of both feet and one hand, as it occurs frequently in patients with diabetes mellitus.

Two-foot, one-hand syndrome is also defined as bilateral plantar tinea pedis with concomitant unilateral tinea manuum. Toenails and fingernails may also be affected and the dermatophyte Trichophyton rubrum is the usual cause. Treatment with an oral antifungal agent should be considered for nail infestations, particularly of the toenails, as topical therapy alone is usually ineffective. However, relapses are common. With the advent of new, more effective antifungal agents such as itraconazole, terbinafine and fluconazole, it is hoped that this troublesome and recalcitrant condition can be better controlled.