MSC Gene

MSC (Musculin) is a protein coding gene located on chromosome 8q13.3. The protein encoded by this gene is a transcriptional repressor that can bind an E-box element in vitro either as a homodimer or as a heterodimer with E2A. This protein complex is capable of inhibiting the transactivation ability of E47, an E2A protein, in mammalian cells.

Diseases associated with MSC include:

• Alk-negative anaplastic large cell lymphoma

and

• rhabdomyosarcoma.

1. Buchanan RM et al (2011) B-cell activating factor (BAFF) promotes CpG ODN-induced B cell activation and proliferation. Cell Immunol 271:16-28.
2. Coffman RL et al (1986) B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol 136:4538-4541.