Deficiency of vitamin B12 (= cobalamin) and/or folic acid with DNA synthesis disorder and nuclear maturation disorder of myelopoesis and occurrence of megaloblasts.
Main symptom: Megaloblastic anemia; in case of vitamin B12 deficiency additional neurological and gastrointestinal symptoms.
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Megaloblastic anemiaD53.1
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The most common are megaloblastic anaemias due to vitamin B12 deficiency. Incidence: 9 cases/100.000 inhabitants/year. Increase in old age