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DefinitionThis section has been translated automatically.
The MAP3K14 gene (MAP3K14 stands for "mitogen-activated protein kinase kinase 14") is a protein-coding gene encoding a serine/threonine protein kinase the mitogen-activated protein kinase kinase 14. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases and is involved in an NF-kappaB-inducing signaling cascade common to tumor necrosis/nerve growth factor (TNF/NGF) family receptors and the interleukin-1 type I receptor.
General informationThis section has been translated automatically.
Diseases associated with MAP3K14 include:
- NIK deficiency (primary immunodeficiency with multiple disorders of lymphoid immunity; ORPHA:447731)
- and
- Ductal adenocarcinoma of the pancreas.
Associated signaling pathways include IL-4 Signaling Pathways and TWEAK Pathway.
LiteratureThis section has been translated automatically.
- Jung JU et al.(2016) NIK/MAP3K14 Regulates Mitochondrial Dynamics and Trafficking to Promote Cell Invasion. Curr Biol 26:3288-3302.
- Otto C et al (2021) Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma. Br J Haematol 157:702-708.
