Mallory body

Mallory FB (1862-1941)

Mallory bodies, also known as Mallory thinking bodies, occur as hepatocellular, cytoplasmic protein aggregates in people with alcoholic and non-alcoholic steatohepatitis, but also in people with obesity permagna (Kücükoglu Ö et al. 2009). They are also found in chronic hepatitis C, primary biliary cirrhosis (Basaranoglu M et al. 2011) and Wilson's disease (in 25% of cases).

MBs consist predominantly of keratin 8 and 18 and can be induced in the mouse model by chronic feeding with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (Kücükoglu Ö et al. 2009).

Apparently, there is a relationship between the severity of fatty liver and the occurrence of MBs (Kayaçetin S et al. 2015).

1. Basaranoglu M et al (2011) Mallory-Denk Bodies in chronic hepatitis.World J Gastroenterol 17:2172-2177.
2. Kayaçetin S et al. (2015) Mallory-Denk bodies: Correlation with steatosis, severity, zonal distribution, and identification with ubiquitin. Turk J Gastroenterol 26:506-510.
3. Kücükoglu Ö et al. (2009) High-fat diet favors Mallory-Denk bodies formation. Z Gastroenterol 47: P1-5