Malassezia-sepsis P36.-; P37.7

Rare, severe catheter-induced systemic infection with Malassezia species (M. pachydermatis, M. furfur), affecting mainly immunocompromised adults or newborns pre-damaged by various diseases. In a larger Southeast Asian study on isolates in sepsis patients (n=2155), Candida species were detected in 91.9% of cases (Lin SY et al. 2019). In the non-yeast isolates (8.1%) 175 non-Candida yeasts could be detected (Lin SY et al. 2019). Of these isolates, 146 could be assigned to the ENSY group (Echinocandin non-susceptible yeast) such as Cryptococcus (109 isolates), Trichosporon (23 isolates), Rhodotorula (10 isolates) and Malassezia (4 isolates).

Nosocomial infection in parenteral nutrition

Azole antifungals: Fluconazole (FLZ), Itraconazole, (ITZ), Posaconazole (POS), Voriconazole (VOR). Antibiograms are useful because in individual cases resistance to azoles is detected (Cafarchia C et al. 2015).

1. Cafarchia C et al (2015) Azole susceptibility of Malassezia pachydermatis and Malassezia furfur and tentative epidemiological cut-off values. Med Mycol 53:743-748.
2. Sizun J et al (1994) Malassezia furfur-related colonization and infection of central venous catheters. A prospective study in a pediatric intensive care unit. Intensive Care Medicine 20: 496-499
3. John G (1985) Catheter-Related Infection in Infants Due to an Unusual Lipophilic Yeast-Malassezia furfur. Pediatrics76: 896-900
4. Lin SY et al (2019) The epidemiology of non-Candida yeast isolated from blood: The Asia Surveillance Study. Mycoses 62:112-120.