The LTB gene (LTB stands for: Lymphotoxin Beta) is a protein coding gene located on chromosome 6p21.33. Alternative splicing leads to several transcript variants that code for different isoforms.
LTB gene
DefinitionThis section has been translated automatically.
General informationThis section has been translated automatically.
The LTB gene codes for lymphotoxin beta. Lymphotoxin beta is a type II membrane protein from the TNF family. It anchors lymphotoxin alpha to the cell surface by forming heterotrimers. The predominant form on the lymphocyte surface is the lymphotoxin alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta), and this complex is the primary ligand for the lymphotoxin beta receptor. The smaller complex is lymphotoxin-alpha 2/beta 1.
LTB is a trigger of the inflammatory response system and is involved in the normal development of lymphoid tissue. The lymphotoxin-beta isoform b cannot form a complex with lymphotoxin-alpha, indicating a function of lymphotoxin-beta independent of lymphotoxin-alpha.
Diseases associated with LTB include synovitis and type 1 diabetes mellitus 21.
LiteratureThis section has been translated automatically.
- Crowe PD et al. (1994) A lymphotoxin-beta-specific receptor. Science 264(5159):707-710.
- Tersteegen A et al. (2021) Lymphotoxin β Receptor: a Crucial Role in Innate and Adaptive Immune Responses against Toxoplasma gondii. Infect Immun 89:e00026-21.