DefinitionThis section has been translated automatically.
LOD is the acronym for "logarithm of the odds or logarithmic odds ratio". In genetics, the LOD score is used as a statistical estimate of the probability that two gene loci on the same chromosome are close to each other and thus inherited in a linked manner.
General informationThis section has been translated automatically.
A LOD score >3 is usually considered an indicator of gene linkage. LOD=3 means that if two gene loci are observed to be transmitted together, it is 1000 times more likely (logarithm to base 10) that the two gene loci were transmitted together due to genetic linkage rather than a random event.
Multilocus linkage analysis can be based on two types of information: pairwise ("pairwise LOD score"), where only two loci are considered at once, and multipoint, where more than two loci are considered.
LOD scores are an important statistical parameter in the identification of quantitative trait loci, chromosomal segments that influence the expression of a particular quantitative trait.
LiteratureThis section has been translated automatically.
This article uses material from the Wikipedia article LOD score and is licensed under the GNU Free Documentation License. A list of authors is available in Wikipedia.
