La antibody

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

SSB antibody; SS-B Antibody

Definition
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Antibody against a 47 kDa RNA-binding nucleoprotein.

Occurrence
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Mainly associated with the Sjögren's syndrome. S.a.u. Sicca symptoms. S.a.u. lupus erythematosus, systemic.

Note(s)
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LA= patient initials.

There is a close connection between Anti-LaSSB and Anti-RoSSA: Ant-RoSSa are detected solitary in many sera, whereas Anti-LaSSB are usually accompanied by Anti-RoSSA.

Literature
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  1. Leung PSC, Gershwin NE (1990) The Molecular structure of autoantigens. Curr. Opin. Immunol. 2: 567-575

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Last updated on: 29.10.2020