Isosorbide-5-mononitrate

Isosorbide-5-mononitrate (ISMN) is a drug with the molecular formula C6H9NO6 for the treatment of angina pectoris or coronary sclerosis. It improves the oxygen supply to the myocardium and simultaneously reduces the oxygen consumption in the myocardium by reducing the so-called preload. Isosorbide dinitrate has an analogous effect.

Isosorbide-5-mononitrate is a very fast but short-acting nitrate, which is therefore well suited for the treatment of an acute attack. After application in the oral cavity (e.g. in tablet form) it takes effect after only a few minutes. The effect lasts for about one hour. The dilatation of veins and vessels reduces the preload of the heart (lowering the end-diastolic pressure). This improves the blood flow in the coronary vessels during diastole. Only in high, non-therapeutic doses do nitrates also have a slight arterial dilating effect.

Acute treatment and prevention of angina pectoris (stage of coronary heart disease CHD caused by coronary sclerosis)

Acute left heart failure .

Coronary spasms (special form of angina pectoris, they are called prinzmetal angina after their discoverer).

Acute heart attack

ISMN AbZ® 40 mg sustained release tablets

1. Graefe KH et al. pharmaceuticals with effects on the vascular system. In: Graefe KH et al (Eds) Pharmacology and Toxicology. Georg Thieme Publisher Stuttgart S.177-181