Interleukin-1 receptor antagonist

The interleukin-1 receptor antagonist is a member of the interleukin-1 cytokine family. The cytokine is encoded by the IL1RN gene, which is located on chromosome 2q14.1 The interleukin-1 receptor antagonist inhibits the activity of interleukin-1 by binding to its receptor(IL1R1) and thus preventing its association with the co-receptor IL1RAP for signal transmission. The interleukin-1 receptor antagonist thus inhibits the activities of interleukin-1 alpha (IL-1alpha) and interleukin-1beta (IL-1beta) and modulates a variety of interleukin-1-related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. Several alternatively spliced transcript variants encoding different isoforms are known.

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