DefinitionThis section has been translated automatically.
The IL7R gene (IL7R stands for Interleukin 7 Receptor) is a protein coding gene located on chromosome 5p13.2. The protein encoded by this gene is a receptor for interleukin-7 (IL-7).
The function of this receptor requires the gamma chain of the interleukin-2 receptor (IL2RG), a common gamma chain of the receptors of several cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development.
LiteratureThis section has been translated automatically.
- Silva A et al (2021) Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma. Blood138:1040-1052.
