IL1R1 gene

IL1R1 (Interleukin 1 Receptor Type 1) is a protein-coding gene located on the gene loci 2q11.2-q12.1. The IL1R1 gene is located in a cluster of related cytokine receptor genes on chromosome 2q12.

The IL1R1 gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for

• interleukin-1-alpha
• interleukin-1-beta and
• interleukin-1 receptor antagonist (Mosley B et al. 1987).

It is an important mediator involved in many cytokine-induced immune and inflammatory responses. Upon binding to the cytokine interleukin-1, the protein complex associates with the coreceptor IL1RAP to form the high-affinity interleukin-1 receptor complex, which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other signaling pathways. The signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88 and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits.

The receptor protein also binds ligands with comparable affinity. Binding of the antagonist IL-1RA prevents binding with IL-1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNgamma production by T helper 1 cells (Th1) (Tominaga K et al. 2000)

Diseases associated with IL1R1 include:

• Chronic Recurrent Multifocal Osteomyelitis 3 (CRI3)

and

• Schnitzler syndrome.

1. Mosley B et al. (1987) The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. J Biol Chem 262:2941-294
2. Tominaga K et al. (2000) IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. Int Immunol 12:151-160.