DefinitionThis section has been translated automatically.
The IL17RB gene (IL17RB stands for: Interleukin 17 Receptor B) is a protein-coding gene that is localized on chromosome 3p21.1. An important paralog of this gene is IL17RA.
ClassificationThis section has been translated automatically.
The IL17RA gene (IL17RA stands for "Interleukin-17 Receptor A") is a protein-coding gene located on chromosome 22q11.
The IL17RC gene (IL17RC stands for "Interleukin 17 Receptor C") is a protein-coding gene located on chromosome 3p25.3.
IL17E (syn: IL-25) is homologous to IL-17E and influences immunological processes of Th2 immunity (see interleukin-17 below). Both cytokines are ligands for the cytokine receptor IL-17RB. IL-17E induces the expression of other cytokines, such as IL-4, IL-5, IL-8 and IL-13.
General informationThis section has been translated automatically.
The protein encoded by this gene is a cytokine receptor. This receptor binds specifically to the proinflammatory cytokines IL17B and IL17E (syn: IL25), but not to the interleukins IL17 and IL17C. The IL17RB receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E (IL25). The expression of the rat counterpart of this gene was found to be significantly upregulated during intestinal inflammation, suggesting an immunoregulatory activity of this receptor
Clinical pictureThis section has been translated automatically.
The receptor protein encoded by this gene may play a role in controlling the growth and/or differentiation of hematopoietic cells.
Diseases associated with IL17RB include transitional papilloma and necrotic uveal melanoma.
