The IL17B gene (IL17B stands for: Interleukin 17B) is a protein-coding gene located on chromosome 5q32. Alternative splicing leads to several splice variants. One of the associated signaling pathways is the IL-17 signaling pathway. An important paralog of this gene is IL17D.
IL17B gene
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General informationThis section has been translated automatically.
The protein encoded by this gene (interleukin-17B) is a T cell-derived cytokine that shares sequence similarity with other members of the interleukin-17 family. This cytokine has been reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of various neural tissues showed that this cytokine is mainly localized in neuronal cell bodies. Interleukin-17B stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
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