IL17B gene

The IL17B gene (IL17B stands for: Interleukin 17B) is a protein-coding gene located on chromosome 5q32. Alternative splicing leads to several splice variants. One of the associated signaling pathways is the IL-17 signaling pathway. An important paralog of this gene is IL17D.

The protein encoded by this gene (interleukin-17B) is a T cell-derived cytokine that shares sequence similarity with other members of the interleukin-17 family. This cytokine has been reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of various neural tissues showed that this cytokine is mainly localized in neuronal cell bodies. Interleukin-17B stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.

1. Wang H, Li C, Chen L, Zhang M, Ren T, Zhang S. Causal relationship between female reproductive factors, sex hormones and uterine leiomyoma: a Mendelian randomization study. Reprod Biomed Online. 2024 Feb;48(2):103584.
2. Buyukcelebi K et al. (2024) Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types. Nat Commun 15:1169.