Ia-2-ac

Anti-IA-2-Ak are antibodies that play a role in the differentiation of diabetes. They are directed against an islet cell membrane protein (ICA512, tyrosine phosphatase IA-2). At 60-80%, IA-2-Ak are slightly less frequently positive for type 1 diabetes than islet cell or GAD65 antibodies.

Anti-IA-2 antibodies are positive in 60-70% of type 1 diabetics and in 2-5% of first-degree relatives in first-degree diabetics. Of these antibody carriers, 65% develop diabetes mellitus within 5 years.

Anti-IA2 antibody is detected by an enzyme linked immunosorbent assay (ELISA) using recombinant human tyrosine phosphatase (IA2) for its quantitative and qualitative determination.

Sample volume: > 75 µL serum

Reference range: < 10 IU/ml

Material: 1 ml serum

Anti-IA2 antibodies and GAD antibodies rarely occur simultaneously, so that antibody determinations complement each other.