Germline mutation

Last updated on: 01.08.2021

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DefinitionThis section has been translated automatically.

A mutation that has arisen in the germ line (egg cell or sperm) of one parent. If it is passed on to a child (50 percent probability), it is detectable in all body cells of the child (again also in cells of the germ line).

General informationThis section has been translated automatically.

If germline mutations imply a pathogenic function, they are defined as inherited mutations of a hereditary disease that can be tested diagnostically pre- and postnatally. In contrast to a germline mutation is the somatic mutation.

Last updated on: 01.08.2021