DefinitionThis section has been translated automatically.
The FUCA2 gene (FUCA2 stands for: alpha-L-fucosidase 2) is a protein-coding gene located on chromosome 6q24.2. An important paralog of this gene is FUCA1.
General informationThis section has been translated automatically.
The FUCA2 gene codes for an alpha-L-fucosidase in plasma, which accounts for 10-20% of total cellular fucosidase activity. Alpha-L-fucosidase is responsible for the hydrolysis of alpha-1,6-linked fucose, which is linked to N-acetylglucosamine at the reducing end of the carbohydrate components of glycoproteins.
Clinical pictureThis section has been translated automatically.
Diseases associated with FUCA2 include fucosidosis with angiokeratomas.
Increased FUCA2 expression in hepatocellular carcinoma is associated with poor prognosis and immune infiltration. FUCA2 may serve as an immunologic and predictive biomarker for HCC (Hu Y et al. 2023).
FUCA2 mediates adhesion between Helicobacter pylori and the gastric mucosa and is upregulated in numerous tumor types.
LiteratureThis section has been translated automatically.
- Duarte JD et al. (2016) Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease. PLoS One 11:e0163013.
- Fu J et al. (2022) Dual role of fucosidase in cancers and its clinical potential. J Cancer13:3121-3132.
- Hu Y et al. (2023) Prognostic and immunological role of alpha-L-fucosidase 2 (FUCA2) in hepatocellular carcinoma. Transl Cancer Res 12:257-272.
