The FGF7 gene (FGF7 stands for: Fibroblast Growth Factor 7) is a protein-coding gene on chromosome 15q21.
FGF7 gene
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The protein encoded by this gene belongs to the family of fibroblast growth factors (FGF-7). Members of the FGF family have broad mitogenic and cellular survival activity and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.
The encoded protein is a potent epithelial cell-specific growth factor whose mitogenic activity is predominantly observed in keratinocytes, but not in fibroblasts and endothelial cells . It is possible that the growth factor is an important paracrine effector of normal epithelial cell proliferation. Studies on mouse and rat homologues of this gene revealed a role in epithelial morphogenesis, wound re-epithelialization (Ågren MS et al. 2022), hair development and early lung organogenesis. The role of the FGF7 protein in arterial pulmonary hypertension still needs to be clarified (Dong H et al. 2021).
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Diseases associated with FGF7 include Apert syndrome. Functions associated with this gene include growth factor activity and chemoattractant activity. An important paralog of this gene is FGF10.
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- Ågren MS et al. (2022) Gene Expression Linked to Reepithelialization of Human Skin Wounds. Int J Mol Sci 23:15746.
- Dong H et al. (2021) Integrated bioinformatic analysis reveals the underlying molecular mechanism of and potential drugs for pulmonary arterial hypertension. Aging (Albany NY) 13:14234-14257.