FGF6 gene

The FGF6 gene (FGF6 stands for: Fibroblast Growth Factor 6) is a protein-coding gene on chromosome 12p13.32.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members have broad mitogenic and cellular survival activity and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The FGF6 gene exhibits oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene has a restricted expression profile, particularly in the myogenic lineage, suggesting a role in muscle regeneration or differentiation.

Annotations associated with this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF4.

Diseases associated with FGF7 include Apert syndrome and hyperphosphataemia.

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