FGA Gene

The FGA gene (FGA stands for "fibrinogen alpha chain") is a protein-coding gene located on chromosome 4q31.3. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing.

The FGA gene encodes the alpha subunit of the clotting factor fibrinogen. Following vascular injury, the encoded preprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin.

Mutations in this gene lead to various diseases, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia, and predominantly renal systemic amyloidosis (AFib amyloidosis - see also hereditary amyloidoses).

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