The EML4 gene (EML4 stands for "EMAP Like 4") is a protein-coding gene located on chromosome 2p21. Alternative splicing of this gene leads to two transcript variants.
EML4 Gene
DefinitionThis section has been translated automatically.
General informationThis section has been translated automatically.
The EML4 gene belongs to the family of microtubule-associated proteins of echinoderms. The encoded WD repeat protein may be involved in microtubule formation. The encoded protein is essential for the formation and stability of microtubules (MTs) (Pollmann M et al. (2006). It is required for mitotic spindle organization and proper attachment of kinetochores to MTs Chen D et al (2015). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (Chen D et al. 2015).
Abnormal fusion of portions of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, resulting in EML4-ALK fusion transcripts, is one of the major mutations associated with non-small cell lung cancer.
LiteratureThis section has been translated automatically.
- Chen D et al (2015) EML4 promotes the loading of NUDC to the spindle for mitotic progression. Cell Cycle 14:1529-1539.
- Chen D et al. (2015) EML4 promotes the loading of NUDC to the spindle for mitotic progression. Cell Cycle 14:1529-1539.
- Pollmann M et al (2006) Human EML4, a novel member of the EMAP family, is essential for microtubule formation. Exp Cell Res 312:3241-3251.