EML4 Gene

The EML4 gene (EML4 stands for "EMAP Like 4") is a protein-coding gene located on chromosome 2p21. Alternative splicing of this gene leads to two transcript variants.

The EML4 gene belongs to the family of microtubule-associated proteins of echinoderms. The encoded WD repeat protein may be involved in microtubule formation. The encoded protein is essential for the formation and stability of microtubules (MTs) (Pollmann M et al. (2006). It is required for mitotic spindle organization and proper attachment of kinetochores to MTs Chen D et al (2015). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (Chen D et al. 2015).

Abnormal fusion of portions of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, resulting in EML4-ALK fusion transcripts, is one of the major mutations associated with non-small cell lung cancer.

1. Chen D et al (2015) EML4 promotes the loading of NUDC to the spindle for mitotic progression. Cell Cycle 14:1529-1539.
2. Chen D et al. (2015) EML4 promotes the loading of NUDC to the spindle for mitotic progression. Cell Cycle 14:1529-1539.
3. Pollmann M et al (2006) Human EML4, a novel member of the EMAP family, is essential for microtubule formation. Exp Cell Res 312:3241-3251.