DefinitionThis section has been translated automatically.
The DNASE2 gene (DNASE2 stands for "Deoxyribonuclease 2, Lysosomal") is a protein-coding gene located at chromosome 19p13.13. The DNASE2 gene encodes a member of the so-called DNase family. DNASE2 is localized in the lysosome and hydrolyzes DNA under acidic conditions. The enzyzm plays an important role in the degradation of nuclear DNA in cellular apoptosis . It is necessary for proper fetal development and for final erythropoiesis in the fetal liver, where it degrades nuclear DNA ejected from erythroid progenitor cells.
Two codominant alleles have been characterized:
- DNASE2*L (low activity) and
- DNASE2*H (high activity), which differ in one nucleotide in the promoter region.
Clinical pictureThis section has been translated automatically.
Diseases associated with DNASE2 include Systemic Lupus Erythematosus and Neonatal Anemia.
LiteratureThis section has been translated automatically.
- Keyel PA (2017) Dnases in health and disease. Dev Biol 429:1-11.
