CLEC4C gene

Last updated on: 10.04.2025

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DefinitionThis section has been translated automatically.

The CLEC4C gene (CLEC4C stands for: C-Type Lectin Domain Family 4 Member C) is a protein-coding gene located on chromosome 12p13.31. Two transcript variants encoding different isoforms have been identified for this gene. Associated signaling pathways include the innate immune system and CLEC7A (Dectin-1) signaling. An important paralog of this gene is CLEC6A.

ClinicThis section has been translated automatically.

Diseases associated with CLEC4C include blastic plasmacytoid dendritic cell neoplasia and cutaneous lupus erythematosus.

LiteratureThis section has been translated automatically.

  1. Dzionek A et al. (2019) BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med 194:1823-1834.
  2. Jégouzo SA et al. (2015) A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2. J Biol Chem 290:16759-1671.
  3. Riboldi E et al. (2011) Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. J Biol Chem 286:35329-35333.

Last updated on: 10.04.2025