The CD79A gene (CD79a molecule) is a protein-coding gene located on chromosome 19q13.2. Alternatively spliced transcript variants encoding different isoforms have been described.
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CD79A Gene
DefinitionThis section has been translated automatically.
PathophysiologyThis section has been translated automatically.
The encoded protein CD79A is required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor (BCR) complex, leading to internalization of the complex, trafficking to endosomes, and antigen presentation.
Furthermore, CD79A is required for BCR surface expression and efficient differentiation of pro- and pre-B cells. It stimulates autophosphorylation and activation of SYK. CD79A also interacts with and increases the activity of some Src family tyrosine kinases. Suppresses BCR signaling during immature B cell development.
Clinical pictureThis section has been translated automatically.
Diseases associated with CD79A include:
Autosomal recessive agammaglobulinemia 3, mutation in CD79A.
Note(s)This section has been translated automatically.
The B lymphocyte antigen receptor (BCR) is a multimeric complex containing the antigen-specific component, surface immunoglobulin (Ig). The surface Ig associates non-covalently with two other proteins, Ig-alpha and Ig-beta, which are necessary for the expression and function of the B-cell antigen receptor (see Fig.).
LiteratureThis section has been translated automatically.
- Chu PG et al (2001) CD79: a review. Appl Immunohistochem Mol Morphol 9: 97-106.
- Minegishi Y et al (1999) Mutations in Ig-alpha (CD79a) result in a complete block in B-cell development. J Clin Invest 104: 1115-1121.
- Wang Y et al (2002) Novel Ig-alpha (CD79a) gene mutation in a Turkish patient with B cell-deficient agammaglobulinemia. Am J Med Genet 108: 333-336.