Cd340

CD340, also known as Cluster of differentiation 340 or HER2, belongs to the family of human epidermal growth factor receptors (HER / EGFR / ERBB). HER2 is an oncogene (gene sequences from normal cells with cancer-inducing activity). The amplification or overexpression of this oncogene plays an important role in the development and progression of certain aggressive types of breast cancer. In recent years, the receptor protein has become an important biomarker. It remains an important therapeutic target for about 30% of breast cancer patients.

ErbB receptors are transmembrane receptors that receive growth signals and transmit them to various signal transduction chains via their cytoplasmic domain, which acts as a tyrosine-specific protein kinase. Of the growth factors that activate these receptors, the epidermal growth factor (EGF) and the transforming growth factor alpha (TGF-alpha) are the most important ligands. There are also a number of other growth factors that can activate one or more ErbB receptors.