CCND1 Gene

The CCND1 (Cyclin D1) gene, abbreviated CCND1, is a protein-coding gene located on chromosome 11q13.3. The protein encoded by this gene belongs to the highly conserved cyclin family, which play an important role during the cell cycle. Cyclins function as regulators of cyclin-dependent kinases (CDK kinases).

Cyclin D1 occupies a central role in the G1-S transition of the cell cycle. Dysregulated cyclin D1 expression plays a crucial pathogenetic role in many different tumors. A dysregulated cyclin D1 expression plays a decisive pathogenetic role in many different tumors. Especially in (cutaneous) B-cell lymphomas(mantle cell lymphoma, multiple myeloma).

Mutations, amplifications, and overexpressions of the CCND1 gene that induce alterations in cell cycle progression are observed in a variety of human tumors. In this context, the methods by which cyclins are misregulated vary widely, ranging from genome amplification to changes in promoter methylation. Cyclin D1 appears to be a cross-cancer player. Cyclin D2 is deregulated in a significant manner only in gliomas.

Diseases associated with CCND1 include:

• Von Hippel-Lindau syndrome
• multiple myeloma
• Mantle cell lymphoma with translocation t(11;14)(q13;q32) with cyclin D1 overexpression via bcl-1 (Navarro A et al. 2020).
• Bronchial carcinomas (Mercapide J et al 2002).
• Ovarian carcinomas (Chang L et al 2018).

1. Chang L et al (2018) LncRNA HOTAIR Regulates CCND1 and CCND2 Expression by Sponging miR-206 in Ovarian Cancer. Cell Physiol Biochem 49:1289-1303.
2. Mercapide J et al (2002) CCND1- and ERBB2-gene deregulation and PTEN mutation analyses in invasive lobular carcinoma of the breast. Mol Carcinog 35:6-12.
3. Navarro A et al (2020) Molecular pathogenesis of mantle cell lymphoma. Hematol Oncol Clin North Am 34:795-807