CAPN14 gene

Last updated on: 15.03.2024

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DefinitionThis section has been translated automatically.

CAPN14 (Calpain 14) is a protein-coding gene located on chromosome 2p23.1.

General informationThis section has been translated automatically.

Calpains are a family of cytosolic calcium-activated cysteine proteases that are involved in a variety of cellular processes, including apoptosis, cell division, modulation of integrin-cytoskeleton interactions and synaptic plasticity (Dear et al. 2000). CAPN14 belongs to the family of large calpain subunits. Calpains are ubiquitously expressed in mammals. They structurally contain two subunits: an 80 kDa catalytic subunit and a 28 kDa regulatory subunit. The latter acts as a chaperone to stabilize the 80 kDa structure.

Diseases associated with CAPN14 include eosinophilic esophagitis and eosinophilic gastritis (Litosh VA et al. 2017).

LiteratureThis section has been translated automatically.

  1. Litosh VA et al. (2017) Calpain-14 and its association with eosinophilic esophagitis. J Allergy Clin Immunol 139:1762-1771.

Last updated on: 15.03.2024