Calcium antagonists, side effects

Calcium channel antagonists are drugs that reduce or prevent the influx of calcium into the cell, thus causing a decoupling of electrical excitation of the cell and muscle contraction: reduction of vascular resistance, especially in the arterial part (vasodilation, RR drop), oxygen conservation.

In dermatology, calcium antagonists are used in the therapy of peripheral circulatory disorders, especially Raynaud's syndrome, but also in systemic scleroderma or systemic lupus erythematosus.

Notice! In women of childbearing age, pregnancy must be ruled out before and during therapy and effective contraception must be used!

• Cutaneous ADRs: Severe skin reactions are possible, especially erythema exsudativum multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, AGEP(pustulose, acute generalized exanthematic) usually occurring 7-10 days after the start of therapy and decreasing 10-14 days after the end of therapy).
• Other possible mucocutaneous ADRs: drug reaction, fixed; erythema, erythromelalgia, allergic skin reactions, hyperhidrosis, gingival hyperplasia, photosensitization.
• Extracutaneous ADRs: headache, bradycardia, hypotension, edema of the legs, gynecomastia (reversible after discontinuation), weight gain, impotence, menstrual disorders, arthralgia, myositis.

Adalat, Aprical, Cisday, Duranifin, Nife, Nifedipate, Nifedipine, Diltiazem

Essential interactions of calcium antagonists