C6 Gene

The C6 gene (C6 stands for "complement C6") is a protein-coding gene located at chromosome 5p13.1. Transcript variants encoding the same protein have been described.

The C6 gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex (MAC), which can be incorporated into the cell membrane and cause cell lysis.

Mutations in this gene are associated with C6 def iciency (C6 complement component 6 deficiency). Patients with C6 deficiency are prone to severe bacterial infections(N.meningitidis).

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