C-type natriuretic peptides
Synonym(s)
CNP; C-type natriuretic peptide
DefinitionThis section has been translated automatically.
The "C-type natriuretic peptide" belongs to the so-called "natriuretic peptides" of the heart (see also BNP, ANP). The natriuretic peptide precursor C, also known as NPPC, is a protein encoded by the NPPC gene in humans.
In contrast to ANP and BNP, CNP has no direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB), whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA). It is synthesized and secreted by the endothelium in response to many stimuli, such as shear stress (like NO) and certain proinflammatory cytokines.
LiteratureThis section has been translated automatically.
- de Bold AJ et al (1981) A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sciences 28: 89-94.
- de Bold AJ (November 1985). Atrial natriuretic factor: a hormone produced by the heart". Science. 230: 767–770.
- Potter LR et al (2009) Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications. Handbook of Experimental Pharmacology. cGMP: Generators, Effectors and Therapeutic Implications. 191st Springer Berlin Heidelberg. SS 341-366.
- Yan W et al (1999). Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart. The Journal of Biological Chemistry. 274: 14926–1435.