C-type natriuretic peptides

The "C-type natriuretic peptide" belongs to the so-called "natriuretic peptides" of the heart (see also BNP, ANP). The natriuretic peptide precursor C, also known as NPPC, is a protein encoded by the NPPC gene in humans.

In contrast to ANP and BNP, CNP has no direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB), whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA). It is synthesized and secreted by the endothelium in response to many stimuli, such as shear stress (like NO) and certain proinflammatory cytokines.

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