Blk gene
Synonym(s)
BLK Nonreceptor Tyrosine Kinase; BLK Proto-Oncogene, Src Family Tyrosine Kinase; B Lymphocyte Kinase; B Lymphoid Tyrosine Kinase; P55-Blk; Tyrosine Protein Kinase Blk
DefinitionThis section has been translated automatically.
The BLK gene (BLK= B lymphocyte kinase) encodes a non-receptor tyrosine kinase (B-lymphocytic tyrosine kinase), which regulates the transcription of genes involved in insulin production and secretion in pancreatic beta cells (Islam KB et al. 1995). The mutations in the BLK gene lead to pathologically decreased insulin production and to the clinical picture of MODY 11. Furthermore, the mutations lead to malfunctions of various pancreatic enzymes (e.g. pancreatic lysophospholipase).
LiteratureThis section has been translated automatically.
- Islam KB et al (1995) Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.J Immunol 154:1265-1272.
- Zhang H et al (2012) The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nature Genet 44: 861-871