DefinitionThis section has been translated automatically.
BDKRB1 (bradykinin receptor B1) is a protein-coding gene located on chromosome 14q32.2. The receptor protein encoded by the BDKRB1 gene belongs to the family of G protein-coupled receptors. An important paralog of this gene is BDKRB2.
General informationThis section has been translated automatically.
Two types of G protein-coupled receptors have been found to bind bradykinin and mediate responses to these pathophysiological conditions.
- Bradykinin receptor B1
- Bradykinin receptor B2
The major ligand of bradykinin receptor B1 is bradykinin, a 9 amino acid peptide that is produced in pathophysiologic conditions such as inflammation, trauma, burns, shock, pruritus and allergy. Binding of the receptor leads to an increase in cytosolic calcium ion concentration, which ultimately leads to chronic and acute inflammatory reactions.
Diseases associated with BDKRB1 include C1 esterase inhibitor deficiency and end-stage renal disease and diabetic retinopathy (Brondani LA et al. 2019).
Neuropathic pain: Bradykinin receptor B1 (BDKRB1) plays an important role in the neuropathic pain signaling pathway (Xie H et al. 2021).
LiteratureThis section has been translated automatically.
Bachvarov DR et al. (1996) Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1). Genomics 33:374-381.
- Brondani LA et al. (2019) The G Allele of the rs12050217 Polymorphism in the BDKRB1 Gene Is Associated with Protection for Diabetic Retinopathy. Curr Eye Res 44:994-999.
- Xie H et al. (2021) Remimazolam alleviates neuropathic pain via regulating bradykinin receptor B1 and autophagy. J Pharm Pharmacol 73:1643-1651.
